Welcome to the Social Welfare Department, also known as Section 2. On the surface, the workers of Section 2 travel from hospital to hospital looking for little girls that have been in serious accidents and are in danger of dying. The MUST not have any surviving family. They take the girls to their special hospital and cure them. Their TRUE purpose is much more sinister. Section 2 is the home of a bunch of Ex Intelligence and Military Personnel and the Gunslinger Girls. Little Girls who have been Altered by Technology to have faster reflexes, perfect hearing and eyesight, and nearly indestructible bodies. They are the assasins of the government, working in the shadows to ensure that the politicians are happy, and therefore no one knows of their existence. Each girl is paired with a handler to which they have sworn absolute loyalty, and are officially known as Fratellos. But technology has a price, and it's something that each little girl has to pay. And sometimes the price can be high.

The anime is mostly focused on Henrietta and her handler Jose but there are actually 6 Gunslinger Girls: Henrietta, Rico, Triela, Angelica, Claes, and Elsa.

This is probably the only anime exclusively set in Italy.

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